KS15

Name: KS15
Brand: AOBIOUS
SKU: AOB17572
Price: 49 USD
Availability: InStock

Cat No: AOB17572

Condition

CAS: 1033781-20-2

Chemical Name: (R,E)-3-(3-(1-(((4-Bromobenzyl)oxy)imino)ethyl)phenyl)-2-ethoxypropanoic acid

More details

978 Item Items

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$41.65	Total: $208.25
1	10	$35.28	Total: $352.80
1	25	$29.89	Total: $747.25
1	50	$25.48	Total: $1,274.00
1	100	$22.05	Total: $2,205.00

Overview

Novel cryptochrome (CRY) inhibitor, enhancing E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex.

Chemical Properties

Molecular Formula	C20H22BrNO4
Molecular Weight	420.30
CAS Numbers	1033781-20-2
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	(R,E)-3-(3-(1-(((4-Bromobenzyl)oxy)imino)ethyl)phenyl)-2-ethoxypropanoic acid
InChl Key	GWSVRVKPZVYTCS-VZMFNRANSA-N
InChl Code	InChI=1S/C20H22BrNO4/c1-3-25-19(20(23)24)12-16-5-4-6-17(11-16)14(2)22-26-13-15-7-9-18(21)10-8-15/h4-11,19H,3,12-13H2,1-2H3,(H,23,24)/b22-14+/t19-/m1/s1
SMILES Code	O=C(O)[C@H](OCC)CC1=CC=CC(/C(C)=N/OCC2=CC=C(Br)C=C2)=C1

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

KS15; KS 15; KS-15

References

1) Jang J, Chung S, Choi Y, Lim HY, Son Y, Chun SK, Son GH, Kim K, Suh YG, Jung JW. The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.

2) Zhu Z, Yang F, Chen P, Liu H, Cao W, Zhang K, Liu X, Zheng H. Emergence of novel Seneca Valley virus strains in China, 2017. Transbound Emerg Dis. 2017 Aug;64(4):1024-1029.

3) Chun SK, Chung S, Kim HD, Lee JH, Jang J, Kim J, Kim D, Son GH, Oh YJ, Suh YG, Lee CS, Kim K. A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells. Biochem Biophys Res Commun. 2015 Nov 13;467(2):441-6.