CB-1158

Numidargistat (CB-1158)

AOB33256

CAS: 2095732-06-0

 

Chemical Name: (3R,4S)-1-(L-Alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid

More details

979 Items

$49.00

$49.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Overview

Novel potent and selective inhibitor of human arginase I, blocking myeloid cell-mediated immune suppression in the tumor microenvironment

Chemical Properties

Molecular FormulaC11H22BN3O5
Molecular Weight287.12
CAS Numbers2095732-06-0
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name(3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
InChl KeyZZJLMZYUGLJBSO-LAEOZQHASA-N
InChl CodeInChI=1S/C11H22BN3O5/c1-7(13)9(16)15-5-8(3-2-4-12(19)20)11(14,6-15)10(17)18/h7-8,19-20H,2-6,13-14H2,1H3,(H,17,18)/t7-,8-,11-/m0/s1
SMILES CodeO=C([C@]1(N)CN(C([C@H](C)N)=O)C[C@@H]1CCCB(O)O)O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

CB-1158 B; CB1158 B; CB 1158 B; INCB01158 B, INCB 01158 B, INCB-01158 B, Numidargistat

References

Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101

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