ML-792

ML-792

AOB37999

CAS: 1644342-14-2

Chemical Name: {(1R,2S,4R)-4-[(5-{[1-(3-Bromobenzyl)-1H-pyrazol-3-yl]carbonyl}pyrimidin-4-yl)amino]-2-hydroxycyclopentyl}methyl sulfamate

More details

986 Items

$35.75

$35.75 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $23.37 Total: $116.87
110 $19.80 Total: $198.00
125 $16.78 Total: $419.38
150 $14.30 Total: $715.00
1100 $12.38 Total: $1,237.50

Overview

Novel potent mechanism-based SUMO-activating enzyme (SAE) inhibitor, selectively blocking SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation










































Chemical Properties

Molecular FormulaC21H23BrN6O5S
Molecular Weight551.42
CAS Numbers1644342-14-2
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name((1R,2S,4R)-4-((5-(1-(3-bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
InChl KeyPZCKLTWSXFDLLP-OGWOLHLISA-N
InChl CodeInChI=1S/C21H23BrN6O5S/c22-15-3-1-2-13(6-15)10-28-5-4-18(27-28)20(30)17-9-24-12-25-21(17)26-16-7-14(19(29)8-16)11-33-34(23,31)32/h1-6,9,12,14,16,19,29H,7-8,10-11H2,(H2,23,31,32)(H,24,25,26)/t14-,16-,19+/m1/s1
SMILES CodeO=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

ML-792; ML 792; ML792

References

1) He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171.

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