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NCGC2955
AOB11639
CAS: 902903-07-5
Chemical Name: NCGC00112955; 1-(4-(4-Chlorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-isopropylpiperidine-4-carboxamide
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $41.65 | Total: $208.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 100 | $22.05 | Total: $2,205.00 |
Overview
Novel Inhibitor of Human Cytomegalovirus (HCMV)
Antiviral Activity
- NCGC2955 was identified as a hit from a large screening (~400,000 compounds) for inhibitors of HCMV replication.
- In vitro, it inhibits HCMV replication at low micromolar concentrations, with EC₅₀ values around ~1.7–2 μM in reporter and plaque assays.
- In testing, NCGC2955 reduced viral protein expression and viral progeny production, indicating it blocks the viral life cycle between early and late stages of infection rather than directly targeting viral DNA polymerase like some traditional antivirals.
Broad‑Spectrum Antiviral Effects (Emerging Evidence)
Some research (preprints and experimental reports) suggests that NCGC2955 and close analogs may also show activity against other viruses, including coronaviruses (e.g., human coronavirus NL63, OC43, and even variants of SARS‑CoV‑2) in cell culture, albeit with varying potencies (in the low µM range).
Mechanism Insight
- The exact molecular mechanism of NCGC2955 is not fully defined publicly.
- It does not strongly inhibit viral DNA replication directly like classic polymerase inhibitors — instead, its activity suggests a different step of viral replication or viral protein processing is affected.
- Because such compounds are identified by phenotype (virus replication inhibition) rather than a known biological target, full mechanistic details often require further biochemical studies.
Usage Context
- NCGC2955 is used in preclinical research, particularly antiviral drug discovery.
- It is not approved for clinical use in humans and is typically handled as a research‑only antiviral probe compound.
Chemical Properties
| Molecular Formula | C23H26ClN3O2S |
| Molecular Weight | 443.99 |
| CAS Numbers | 902903-07-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 1-(4-(4-Chlorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-isopropylpiperidine-4-carboxamide |
| InChl Key | RVJDVTNRTMXNGU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H26ClN3O2S/c1-15(2)25-22(28)17-7-10-26(11-8-17)23(29)20-13-21-19(9-12-30-21)27(20)14-16-3-5-18(24)6-4-16/h3-6,9,12-13,15,17H,7-8,10-11,14H2,1-2H3,(H,25,28) |
| SMILES Code | O=C(C1CCN(C(C2=CC3=C(C=CS3)N2CC4=CC=C(Cl)C=C4)=O)CC1)NC(C)C |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
NCGC2955; NCGC-2955; NCGC 2955; NCGC00112955
References
1) Guo X, Ghosh AK, Keyes RF, Peterson F, Forman M, Meyers DJ, Arav-Boger R. The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides. Viruses. 2022 Jan 25;14(2):234. doi: 10.3390/v14020234. PMID: 35215828; PMCID: PMC8876412.