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PFK-158
AOB8923
CAS: 1462249-75-7
Chemical Name: (E)-1-Pyridin-4-yl-3-[7-(trifluoromethyl)quinolin-2-yl]prop-2-en-1-one
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Overview
Novel inhibitor of PFKFB3, displaying broad anti-tumor activity
Chemical Properties
| Molecular Formula | C18H11F3N2O |
| Molecular Weight | 328.29 |
| CAS Numbers | 1462249-75-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (E)-1-(pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one |
| InChl Key | IAJOMYABKVAZCN-AATRIKPKSA-N |
| InChl Code | InChI=1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+ |
| SMILES Code | O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PFK158; PFK 158; PFK158; ACTPFK158.
References
1) Zhang Y, Wang X, Li X, Dong L, Hu X, Nie T, Lu Y, Lu X, Pang J, Li G, Yang X, Li C, You X. Synergistic Effect of Colistin Combined with PFK-158 against Colistin-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00271-19. doi: 10.1128/AAC.00271-19. Print 2019 Jul. PubMed PMID: 30988150; PubMed Central PMCID: PMC6591609.