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CD38-IN-78c
AOB17655
CAS: 1700637-55-3
Chemical Name: CD38 inhibitor 78c; 4-(((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-on
999 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Novel potent protease inhibitor with anti-viral activity against SARS-CoV-2
Novel highly potent CD38 inhibitor, demonstrating cardiac protection effect in an ex vivo model of I/R
Chemical Properties
| Molecular Formula | C22H27N3O3S |
| Molecular Weight | 413.54 |
| CAS Numbers | 1700637-55-3 |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone |
| InChl Key | VJQALSOBHVEJQM-QAQDUYKDSA-N |
| SMILES Code | COCCO[C@H]1CC[C@H](NC2=CC(N(C3=CC=C(C4=CN=CS4)C=C23)C)=O)CC1 |
| PubChem ID | 118736856 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
CD38 inhibitor 78c
References
1) Tarrago et al (2018) A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD+ decline. Cell Metab. 27 1081 PMID: 29719225
2) Haffner et al (2015) Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors. J.Med.Chem. 58 3548 PMID: 25828863
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