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M3258
AOB12137
CAS: 1637542-33-6
Chemical Name: Peposertib; Nedisertib; MSC2490484A; (S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $41.65 | Total: $208.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 100 | $22.05 | Total: $2,205.00 |
Overview
Novel inhibitor of DNA-dependent protein kinase (DNA-PK)
Chemical Properties
| Molecular Formula | C17H20BNO5 |
| Molecular Weight | 329.2 |
| CAS Numbers | 2285330-15-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
M3258, M 3258
References
1) Klein M, et al. Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) [published online ahead of print, 2021 Jul 6]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00604.
2) Sanderson MP, et al. M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models [published online ahead of print, 2021 May 27]. Mol Cancer Ther. 2021;10.1158/1535-7163.MCT-21-0005.CID: PMC7884679.