SC13

FEN1 inhibitor SC13

AOB14637

CAS 2098776-03-3

Chemical Name: N-(3-((2,4-Dioxo-3-propyl-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)phenyl)-2-phenylacetamide

More details

1977 Items

In stock

$27.00

$27.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $22.95 Total: $114.75
110 $19.44 Total: $194.40
125 $16.47 Total: $411.75
150 $14.04 Total: $702.00
1100 $12.15 Total: $1,215.00

Overview

Novel FEN1 inhibitor, greatly sensitizing cancer cells to low-dose camptothecin

Chemical Properties

Molecular FormulaC30H27N3O15
Molecular Weight669.55
CAS Numbers2098776-03-3
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical NameN-(3-((2,4-dioxo-3-propyl-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)phenyl)-2-phenylacetamide
InChl KeyUSTMMKOHIRMBIV-UHFFFAOYSA-N
InChl Code InChI=1S/C24H23N3O3S/c1-2-12-26-23(29)22-20(11-13-31-22)27(24(26)30)16-18-9-6-10-19(14-18)25-21(28)15-17-7-4-3-5-8-17/h3-11,13-14H,2,12,15-16H2,1H3,(H,25,28)
SMILES CodeO=C(NC1=CC=CC(CN(C(C=CS2)=C2C(N3CCC)=O)C3=O)=C1)CC4=CC=CC=C4

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

SC13; SC 13; SC-13;

References

1) JL, Wang JP, Chang H, Deng SM, Du JH, Wang XX, Hu HJ, Li DY, Xu XB, Guo WQ, Song YH, Guo Z, Sun MX, Wu YW, Liu SB. FEN1 inhibitor increases sensitivity of radiotherapy in cervical cancer cells. Cancer Med. 2019 Dec;8(18):7774-7780. doi: 10.1002/cam4.2615. Epub 2019 Oct 31. PMID: 31670906; PMCID: PMC6912068.

2) He L, Yang H, Zhou S, Zhu H, Mao H, Ma Z, Wu T, Kumar AK, Kathera C, Janardhan A, Pan F, Hu Z, Yang Y, Luo L, Guo Z. Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells. DNA Repair (Amst). 2018 Mar;63:1-9. doi: 10.1016/j.dnarep.2018.01.003. Epub 2018 Jan 9. PMID: 29358095.

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