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Ru.365
AOB37988
CAS: 944776-37-8
Chemical Name: RU166365; 3-[1-(1H-Benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one; ; 2-(1H-Benzimidazol-2-yl)-5-methyl-4-(3-oxo-1H-2-benzofuran-1-yl)-1H-pyrazol-3-one
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $58.65 | Total: $293.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 100 | $31.05 | Total: $3,105.00 |
Overview
Novel selective inhibitor of cyclic GMP-AMP synthase (cGAS)
Chemical Properties
| Molecular Formula | C19H14N4O3 |
| Molecular Weight | 346.35 |
| CAS Numbers | 944776-37-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-[1-(1H-Benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one; ; 2-(1H-Benzimidazol-2-yl)-5-methyl-4-(3-oxo-1H-2-benzofuran-1-yl)-1H-pyrazol-3-one |
| InChl Key | OHRRAFUHDWTHIV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H14N4O3/c1-10-15(16-11-6-2-3-7-12(11)18(25)26-16)17(24)23(22-10)19-20-13-8-4-5-9-14(13)21-19/h2-9,16,22H,1H3,(H,20,21) |
| SMILES Code | CC1=C(C(=O)N(N1)C2=NC3=CC=CC=C3N2)C4C5=CC=CC=C5C(=O)O4 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
RU166365
References
1) Jessica Vincent et al., Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice, Nature Communications volume 8, Article number: 750 (2017)