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BM221
AOB12963
CAS N/A
Chemical Name: Ac-Phe-Lys-Pro-Leu-Ala-Abu-D-Ala-Arg-OH
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $109.65 | Total: $548.25 |
| 1 | 10 | $92.88 | Total: $928.80 |
| 1 | 25 | $78.69 | Total: $1,967.25 |
| 1 | 50 | $67.08 | Total: $3,354.00 |
| 1 | 100 | $58.05 | Total: $5,805.00 |
Overview
Novel potent and stable peptide C5aR1 agonist, inducing C5aR1-mediated calcium mobilization and pERK1/2 signaling, and β-arrestin recruitment
Chemical Properties
| Molecular Formula | C44H72N12O10 |
| Molecular Weight | 929.13 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | ((S)-2-((S)-2-((S)-2-((S)-1-(acetyl-L-phenylalanyl-L-lysyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)propanamido)butanoyl)-D-alanyl-L-arginine |
| InChl Key | XDOOBNYHWWUCRX-ZNLDZGKTSA-N |
| InChl Code | InChI=1S/C44H72N12O10/c1-7-30(38(60)49-27(5)37(59)54-32(43(65)66)18-13-21-48-44(46)47)52-36(58)26(4)50-39(61)33(23-25(2)3)55-41(63)35-19-14-22-56(35)42(64)31(17-11-12-20-45)53-40(62)34(51-28(6)57)24-29-15-9-8-10-16-29/h8-10,15-16,25-27,30-35H,7,11-14,17-24,45H2,1-6H3,(H,49,60)(H,50,61)(H,51,57)(H,52,58)(H,53,62)(H,54,59)(H,55,63)(H,65,66)(H4,46,47,48)/t26-,27+,30-,31-,32-,33-,34-,35-/m0/s1 |
| SMILES Code | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC)C(N[C@H](C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)C |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
BM221; BM 221; BM-221
References
1) Gorman DM, Li XX, Lee JD, Fung JN, Cui CS, Lee HS, Rolfe BE, Woodruff TM, Clark RJ. Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. J Med Chem. 2021 Nov 25;64(22):16598-16608. doi: 10.1021/acs.jmedchem.1c01174. Epub 2021 Nov 11. PMID: 34762432.