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Overview
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
Chemical Properties
| Molecular Formula | C12H14N2O2 |
| Molecular Weight | 218.25 |
| CAS Numbers | 110117-83-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cn1cc(C[C@@H](N)C(O)=O)c2ccccc12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Hou DY, et al. Cancer Res. 2007, 67[2], 792-801.