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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $72.25 | Total: $361.25 |
| 1 | 10 | $61.20 | Total: $612.00 |
| 1 | 25 | $51.85 | Total: $1,296.25 |
| 1 | 50 | $44.20 | Total: $2,210.00 |
| 1 | 100 | $38.25 | Total: $3,825.00 |
Overview
AZ12601011 is an orally active, selective and potent TGFBR1 kinase inhibitor.AZ12601011 inhibits the release of inflammatory factors, interleukin (IL)-1?, IL-6 and tumor necrosis factor-?, and inhibits the growth of breast tumors.AZ12601011 directly binds to TGF-?R1 and blocks downstream Smad3 activation, which can be used to prevent renal fibrosis.
Chemical Properties
| Molecular Formula | C19H15N5 |
| Molecular Weight | 313.36 |
| CAS Numbers | 2748337-86-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N=1C=CC2=C(C1)C=CN2C3=NC(=NC4=C3CCC4)C5=NC=CC=C5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor ?Superfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95[2] 222-234.