Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
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- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
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- Rare Chemicals
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- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $85.00 | Total: $425.00 |
| 1 | 10 | $72.00 | Total: $720.00 |
| 1 | 25 | $61.00 | Total: $1,525.00 |
| 1 | 50 | $52.00 | Total: $2,600.00 |
| 1 | 100 | $45.00 | Total: $4,500.00 |
Overview
GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAPTAZ activation, and can be used to study YAPTAZ-dependent tumors.
Chemical Properties
| Molecular Formula | C28H29FN6O2 |
| Molecular Weight | 500.57 |
| CAS Numbers | 2648450-42-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1C=C(NC2=C(C(=O)N3CC(CF)C3)C(=NN12)C=4N=CC=NC4C)C=5C=CC(=CC5)C6CCCCC6 |
Storage and Handling
0C Short Term, -20C Long Term
References
Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAPTAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4[6] 812-828.