Categories
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- Protein Control Ligand
- Pathway Inhibitors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $25.50 | Total: $127.50 |
| 1 | 10 | $21.60 | Total: $216.00 |
| 1 | 25 | $18.30 | Total: $457.50 |
| 1 | 50 | $15.60 | Total: $780.00 |
| 1 | 100 | $13.50 | Total: $1,350.00 |
Overview
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 ?M) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 ?M), but highly effective against ROCK1 (IC50: 100 nM).
Chemical Properties
| Molecular Formula | C19H16FN5O2 |
| Molecular Weight | 365.36 |
| CAS Numbers | 817194-38-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Homan KT, et al. ACS Chem Biol. 2015, 10[1] 310-9.