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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $25.50 | Total: $127.50 |
| 1 | 10 | $21.60 | Total: $216.00 |
| 1 | 25 | $18.30 | Total: $457.50 |
| 1 | 50 | $15.60 | Total: $780.00 |
| 1 | 100 | $13.50 | Total: $1,350.00 |
Overview
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Chemical Properties
| Molecular Formula | C20H12Cl4N2O2 |
| Molecular Weight | 454.13 |
| CAS Numbers | 548779-60-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Clc1ccc(Cl)c(c1)C(=O)Nc1ccc(NC(=O)c2cc(Cl)ccc2Cl)cc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Fan C W , Chen B , Franco I , et al. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation[J]. Cell Chemical Biology, 2014, 21[12] 1680-1689.