Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $274.55 | Total: $1,372.75 |
| 1 | 10 | $232.56 | Total: $2,325.60 |
| 1 | 25 | $197.03 | Total: $4,925.75 |
| 1 | 50 | $167.96 | Total: $8,398.00 |
| 1 | 100 | $145.35 | Total: $14,535.01 |
Overview
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability in in vitro and in vivo assays and has a favorable overall ADME profile.
Chemical Properties
| Molecular Formula | C43H54Cl2F2N8O6Si |
| Molecular Weight | 915.93 |
| CAS Numbers | 1334314-19-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COC(N[C@@H](C(C)C)C(N1[C@@H](C[Si](C)(C1)C)C2=NC3=C(C4=CC=C(C5=CC=C(C6=CN=C([C@H]7N(CC(F)(C7)F)C([C@H](C(C)C)NC(OC)=O)=O)N6)C=C5)C=C4C=C3)N2)=O)=O.Cl.Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
Nair AG, et al. MK-8325 A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett. 2018;28[10] 1954-1957.