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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $190.40 | Total: $952.00 |
| 1 | 10 | $161.28 | Total: $1,612.80 |
| 1 | 25 | $136.64 | Total: $3,416.00 |
| 1 | 50 | $116.48 | Total: $5,824.00 |
| 1 | 100 | $100.80 | Total: $10,080.00 |
Overview
NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
Chemical Properties
| Molecular Formula | C23H24N8O3 |
| Molecular Weight | 460.49 |
| CAS Numbers | 2272904-53-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC |
Storage and Handling
0C Short Term, -20C Long Term
References
Leit S, et al. Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor TAK-279. J Med Chem. 2023;66[15] 10473-10496.