Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
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- TNF Receptors
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- Tissue Microarray (TMA)
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- Primary Cells
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $95.20 | Total: $476.00 |
| 1 | 10 | $80.64 | Total: $806.40 |
| 1 | 25 | $68.32 | Total: $1,708.00 |
| 1 | 50 | $58.24 | Total: $2,912.00 |
| 1 | 100 | $50.40 | Total: $5,040.00 |
Overview
NT219 is a dual inhibitor of insulin receptor substrate 12 (IRS12) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylation NT219 is useful for the study of cancer and neurodegenerative diseases.
Chemical Properties
| Molecular Formula | C16H14BrNO5S |
| Molecular Weight | 412.26 |
| CAS Numbers | 1198078-60-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Oc1ccc(C=CC(=S)NCc2cc(O)c(O)c(O)c2)c(Br)c1O |
Storage and Handling
0C Short Term, -20C Long Term
References
Alberto Bessudo, et al. A phase 12 study with open-label, dose escalation phase followed by single-arm expansion at the maximum tolerated dose to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of NT219 injection alone and in combination with cetuximab in adults with advanced solid tumors and head and neck cancer.