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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Overview
Brepocitinib (PF-06700841) is a potent dual JAK1TYK2 inhibitor with IC50 values of 17 nM and 23 nM, respectively, and also inhibits JAK2 and JAK3 with IC50 values of 77 nM and 6.49 ?M.
Chemical Properties
| Molecular Formula | C18H21F2N7O |
| Molecular Weight | 389.4 |
| CAS Numbers | 1883299-62-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(=O)(N1C2CN(CC1CC2)C3=NC(NC=4C=NN(C)C4)=NC=C3)[C@H]5C(F)(F)C5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases Discovery of [[ S]-2,2-Difluorocyclopropyl][[1 R,5 S]-3-[2-[[1-methyl-1 H-pyrazol-4-yl]amino]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone [PF-06700841]. J Med Chem. 2018 Oct 11;61[19] 8597-8612.