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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Overview
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 ?M and p-ERK modulation in cells IC50 = 0.250 ?M). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
Chemical Properties
| Molecular Formula | C16H19Cl2N5 |
| Molecular Weight | 352.26 |
| CAS Numbers | 1801747-42-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun. 2018 Oct 30;9[1] 4508. doi 10.1038s41467-018-06823-9.