Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $73.95 | Total: $369.75 |
| 1 | 10 | $62.64 | Total: $626.40 |
| 1 | 25 | $53.07 | Total: $1,326.75 |
| 1 | 50 | $45.24 | Total: $2,262.00 |
| 1 | 100 | $39.15 | Total: $3,915.00 |
Overview
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 ?M) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.
Chemical Properties
| Molecular Formula | C37H53N5O8S |
| Molecular Weight | 727.91 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN(CCOCCN1C)C(C2=CC3=C(C=CC(OC)=C3)C4=C(C5CCCCC5)C(C=CC(C(O)=NS1(=O)=O)=C6)=C6N4C2)=O.OCC[N+](C)(C)C.[OH-] |
Storage and Handling
0C Short Term, -20C Long Term
References
Wang H, et al. Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC64705Biochem Cell Biol. 2016 Apr;94[2] 147-58.