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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $59.50 | Total: $297.50 |
| 1 | 10 | $50.40 | Total: $504.00 |
| 1 | 25 | $42.70 | Total: $1,067.50 |
| 1 | 50 | $36.40 | Total: $1,820.00 |
| 1 | 100 | $31.50 | Total: $3,150.00 |
Overview
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 ?M). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apoptosis. telomerase-IN-1 leads to inhibition of cell proliferation through the expression of downstream signaling molecules including Telomease-IN-1 has high inhibitory activity against telomerase, high anti-proliferative capacity against SMMC-7721 cells, and no significant toxic effect on human normal hepatocytes. telomerase-IN-1 in xenograft tumor model exhibited antitumor activity.
Chemical Properties
| Molecular Formula | C21H23FN2O4 |
| Molecular Weight | 386.42 |
| CAS Numbers | 666859-49-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COC(CN1CCC(CC1)C(=O)c1ccc(F)cc1)c1ccc(cc1)[N+]([O-])=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Cheng X, et al. Discovery of [4-bromophenyl][3-hydroxy-4-methoxyphenyl]methanone through upregulating hTERT induces cell apoptosis and ERS. Cell Death Dis. 2017;8[8] 3016.