Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $141.95 | Total: $709.75 |
| 1 | 10 | $120.24 | Total: $1,202.40 |
| 1 | 25 | $101.87 | Total: $2,546.75 |
| 1 | 50 | $86.84 | Total: $4,342.00 |
| 1 | 100 | $75.15 | Total: $7,515.00 |
Overview
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 ?M for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
Chemical Properties
| Molecular Formula | C18H17F4N3O3 |
| Molecular Weight | 399.34 |
| CAS Numbers | 2007885-39-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F |
Storage and Handling
0C Short Term, -20C Long Term
References
Rowbottom MW, et al. Identification of 4-[Aminomethyl]-6-[trifluoromethyl]-2-[phenoxy]pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 [LOXL2]. J Med Chem. 2017 May 25;60[10] 4403-4423.