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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $96.05 | Total: $480.25 |
| 1 | 10 | $81.36 | Total: $813.60 |
| 1 | 25 | $68.93 | Total: $1,723.25 |
| 1 | 50 | $58.76 | Total: $2,938.00 |
| 1 | 100 | $50.85 | Total: $5,085.00 |
Overview
EW-7195 is a selective and potent inhibitor of ALK5 (TGF?R1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38?.EW-7195 has an inhibitory effect on TGF-?1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.
Chemical Properties
| Molecular Formula | C23H18N8 |
| Molecular Weight | 406.44 |
| CAS Numbers | 1352609-28-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cc1cccc(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Park CY, et al. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung. Eur J Cancer. 2011;47[17] 2642-2653.