Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $155.55 | Total: $777.75 |
| 1 | 10 | $131.76 | Total: $1,317.60 |
| 1 | 25 | $111.63 | Total: $2,790.75 |
| 1 | 50 | $95.16 | Total: $4,758.00 |
| 1 | 100 | $82.35 | Total: $8,235.00 |
Overview
JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
Chemical Properties
| Molecular Formula | C19H16N8O |
| Molecular Weight | 372.38 |
| CAS Numbers | 2445499-20-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC=1C(=NC(NC2=CN(CC#N)N=C2)=NC1)C3=CC=C(C(NCC#N)=O)C=C3 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhaokui WAN, et al. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof. WO2020119819.