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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $36.55 | Total: $182.75 |
| 1 | 10 | $30.96 | Total: $309.60 |
| 1 | 25 | $26.23 | Total: $655.75 |
| 1 | 50 | $22.36 | Total: $1,118.00 |
| 1 | 100 | $19.35 | Total: $1,935.00 |
Overview
PKM2 activator 2, with an AC50 value of 66 nM, is a pyruvate kinase M2 (PKM2) activator that demonstrates anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through the activation of PKM2.
Chemical Properties
| Molecular Formula | C20H18F2N2O4S2 |
| Molecular Weight | 452.49 |
| CAS Numbers | 1186660-06-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Fc1cccc(F)c1S(=O)(=O)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010;53[3] 1048-1055.