Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $113.90 | Total: $569.50 |
| 1 | 10 | $96.48 | Total: $964.80 |
| 1 | 25 | $81.74 | Total: $2,043.50 |
| 1 | 50 | $69.68 | Total: $3,484.00 |
| 1 | 100 | $60.30 | Total: $6,030.00 |
Overview
AKE-72 is a Pan-BCR-ABL inhibitor with anti-leukemic activity.AKE-72 inhibits the proliferation of BaF3 cells expressing natural BCR-ABL or its T315I mutant.
Chemical Properties
| Molecular Formula | C30H29F3N6O |
| Molecular Weight | 546.59 |
| CAS Numbers | 2566525-18-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C=3C=CC=C(C#CC4=CC=CC=5NN=C(N)C45)C3 |
Storage and Handling
0C Short Term, -20C Long Term
References
El-Damasy AK,et al. Discovery of 3-[[3-amino-1H-indazol-4-yl]ethynyl]-N-[4-[[4-ethylpiperazin-1-yl]methyl]-3-[trifluoromethyl]phenyl]benzamide [AKE-72], a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant. J Enzyme Inhib Med Chem. 2023 Dec;38[1] 2228515.