Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
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- Nuclear Receptor Ligands
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $69.70 | Total: $348.50 |
| 1 | 10 | $59.04 | Total: $590.40 |
| 1 | 25 | $50.02 | Total: $1,250.50 |
| 1 | 50 | $42.64 | Total: $2,132.00 |
| 1 | 100 | $36.90 | Total: $3,690.00 |
Overview
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.
Chemical Properties
| Molecular Formula | C21H13ClF3N3O2 |
| Molecular Weight | 431.8 |
| CAS Numbers | 1400989-25-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)c1cc(NC(=O)Nc2cccc(Oc3ccc(cc3)C#N)c2)ccc1Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling A promising therapeutic approach for the treatment of cholangiocarcinoma. Oncotarget. 2017 May 10;8[39] 65077-65089.