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GW8510
AOB2086
CAS No: 222036-17-1
Chemical Name: 4-{[(7-Oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-N-(2-pyridyl)benzenesulfonamide
809 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $41.65 | Total: $208.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 100 | $22.05 | Total: $2,205.00 |
Overview
Inhibitor of cyclin kinase 2 (CDK2)
Chemical Properties
| Molecular Formula | C21H15N5O3S2 |
| Molecular Weight | 449.51 |
| CAS Numbers | 222036-17-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 4-{[(7-Oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-N-(2-pyridyl)benzenesulfonamide |
| InChl Key | GCYXEGSPUDSZJY-PTNGSMBKSA-N |
| InChl Code | InChI=1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27)/b15-11- |
| SMILES Code | O=S(C1=CC=C(N/C=C2C(NC3=C2C(SC=N4)=C4C=C3)=O)C=C1)(NC5=NC=CC=C5)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
GW8510; GW-8510; GW 8510
References
1) Chen P, Wu JN, Shu Y, Jiang HG, Zhao XH, Qian H, Chen K, Lan T, Chen CG, Li J. Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction. Clin Sci (Lond). 2018 May 31. pii: CS20180010.
2) Guyett PJ, Xia S, Swinney DC, Pollastri MP, Mensa-Wilmot K. Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome. ACS Infect Dis. 2016 Jul 8;2(7):518-28.
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