SBFI-26

SBFI-26

AOB31865

CAS No: 1541209-75-9

 

Chemical Name: SB-FI-26; 2,4-Diphenyl-cyclobutane-1,3-dicarboxylic acid mono-naphthalen-1-yl ester monosodium salt

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Discontinued product that has been withdrawn from sale for commercial reasons

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Overview

Novel Fatty Acid Binding Protein (FABP) inhibitor, binding to anandamide transporters FABP5 and FABP7 at two different sites; Anti-nociceptive

Chemical Properties

Molecular FormulaC28H21NaO4
Molecular Weight444.46
CAS Numbers1541209-75-9
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name(1R,2R,3R,4R)-3-((naphthalen-1-yloxy)carbonyl)-2,4-diphenylcyclobutane-1-carboxylic acid
InChl KeyNVOKBONTLOAJKA-VEYUFSJPSA-N
InChl CodeInChI=1S/C28H22O4/c29-27(30)25-23(19-11-3-1-4-12-19)26(24(25)20-13-5-2-6-14-20)28(31)32-22-17-9-15-18-10-7-8-16-21(18)22/h1-17,23-26H,(H,29,30)/t23-,24-,25-,26-/m1/s1
SMILES CodeO=C([C@H]1[C@H](C2=CC=CC=C2)[C@H](C(O)=O)[C@H]1C3=CC=CC=C3)OC4=C5C=CC=CC5=CC=C4

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

SB-FI-26; SBFI26; SBFI 26; SBFI-26

References

1) Al-Jameel W, Gou X, Forootan SS, Al Fayi MS, Rudland PS, Forootan FS, Zhang J, Cornford PA, Hussain SA, Ke Y. Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5. Oncotarget. 2017 May 9;8(19):31041-31056.

2) Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. Biochemistry. 2017 Jul 11;56(27):3454-3462.

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