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Crebinostat
AOB9779
CAS NO: 1092061-61-4
Chemical Name: 7-(2-([1,1'-Biphenyl]-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide
360 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $16.15 | Total: $80.75 |
| 1 | 10 | $13.68 | Total: $136.80 |
| 1 | 25 | $11.59 | Total: $289.75 |
| 1 | 50 | $9.88 | Total: $494.00 |
| 1 | 100 | $8.55 | Total: $855.00 |
Overview
Novel HDAC inhibitor, inhibiting HDACs 1-3 and 6; and inducing histone acetylation; Regulator of neuronal genes involved in synaptic function and cognition; Enhancer of performance in fear conditioning learning in mice
Chemical Properties
| Molecular Formula | C20H23N3O3 |
| Molecular Weight | 353.41 |
| CAS Numbers | 1092061-61-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 7-(2-([1,1'-Biphenyl]-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide |
| InChl Key | AEIVDBATQVVQFS-RCCKNPSSSA-N |
| InChl Code | InChI=1S/C20H23N3O3/c24-19(9-5-2-6-10-20(25)23-26)22-21-15-16-11-13-18(14-12-16)17-7-3-1-4-8-17/h1,3-4,7-8,11-15,26H,2,5-6,9-10H2,(H,22,24)(H,23,25)/b21-15+ |
| SMILES Code | O=C(NO)CCCCCC(N/N=C/C1=CC=C(C2=CC=CC=C2)C=C1)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Crebinostat
References
1) Ghosh B, et al. Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-1271. doi: 10.1016/j.bmcl.2016.01.022. Epub 2016 Jan 11. PubMed PMID: 26804233; PubMed Central PMCID: PMC4753070.
2) Fass DM, et al., Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 2013 Jan;64:81-96. doi: 10.1016/j.neuropharm.2012.06.043. Epub 2012 Jul 4. PubMed PMID: 22771460; PubMed Central PMCID: PMC3447535.
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