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EPZ-719
AOB12228
CAS: 2697176-16-0
Chemical Name: 4-Fluoro-7-methyl-N-((1R,3S)-3-((S)-3-(N-methylmethylsulfonamido)pyrrolidin-1-yl)cyclohexyl)-1H-indole-2-carboxamide
991 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $101.15 | Total: $505.75 |
| 1 | 10 | $85.68 | Total: $856.80 |
| 1 | 25 | $72.59 | Total: $1,814.75 |
| 1 | 50 | $61.88 | Total: $3,094.00 |
| 1 | 100 | $53.55 | Total: $5,355.00 |
Overview
First-in-Class Inhibitor of the Histone Methyltransferase SETD2 with a high selectivity over other histone methyltransferases
Chemical Properties
| Molecular Formula | C22H31FN4O3S |
| Molecular Weight | 450.57 |
| CAS Numbers | 2697176-16-0 (free base) |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 4-fluoro-7-methyl-N-((1R,3S)-3-((S)-3-(N-methylmethylsulfonamido)pyrrolidin-1-yl)cyclohexyl)-1H-indole-2-carboxamide |
| InChl Key | ZLVKIBLQXFILMA-IKGGRYGDSA-N |
| InChl Code | InChI=1S/C22H31FN4O3S/c1-14-7-8-19(23)18-12-20(25-21(14)18)22(28)24-15-5-4-6-16(11-15)27-10-9-17(13-27)26(2)31(3,29)30/h7-8,12,15-17,25H,4-6,9-11,13H2,1-3H3,(H,24,28)/t15-,16+,17+/m1/s1 |
| SMILES Code | O=C(C(N1)=CC2=C1C(C)=CC=C2F)N[C@H]3C[C@@H](N4C[C@@H](N(C)S(=O)(C)=O)CC4)CCC3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
EPZ-719; EPZ719; EPZ 719;
References
1) Lampe JW, Alford JS, Boriak-Sjodin PA, Brach D, Cosmopoulos K, Duncan KW, Eckley ST, Foley MA, Harvey DM, Motwani V, Munchhof MJ, Raimondi A, Riera TV, Tang C, Thomenius MJ, Totman J, Farrow NA. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545. doi: 10.1021/acsmedchemlett.1c00272. PMID: 34671445; PMCID: PMC8521618.