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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Overview
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families.
Chemical Properties
| Molecular Formula | C19H27N3O2 |
| Molecular Weight | 329.44 |
| CAS Numbers | 1527503-11-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Pappano WN, et al. PLoS One. 2015, 10[7] e0131716.