Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $85.85 | Total: $429.25 |
| 1 | 10 | $72.72 | Total: $727.20 |
| 1 | 25 | $61.61 | Total: $1,540.25 |
| 1 | 50 | $52.52 | Total: $2,626.00 |
| 1 | 100 | $45.45 | Total: $4,545.00 |
Overview
GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.
Chemical Properties
| Molecular Formula | C25H29N3O5 |
| Molecular Weight | 451.51 |
| CAS Numbers | 1926989-06-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(CC=CC)c(=O)c2[nH]c(C)cc12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27[15] 3534-3541.