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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $27.20 | Total: $136.00 |
| 1 | 10 | $23.04 | Total: $230.40 |
| 1 | 25 | $19.52 | Total: $488.00 |
| 1 | 50 | $16.64 | Total: $832.00 |
| 1 | 100 | $14.40 | Total: $1,440.00 |
Overview
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
Chemical Properties
| Molecular Formula | C18H15N5O |
| Molecular Weight | 317.34 |
| CAS Numbers | 1140964-99-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23 |
Storage and Handling
0C Short Term, -20C Long Term
References
McGonigle S, Chen Z, Wu J, et al. E7449 A dual inhibitor of PARP12 and tankyrase12 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015;6[38] 41307-41323. doi 10.18632oncotarget.5846