Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
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- Cytokine Receptors
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- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
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- Antifungal
- Antioxidant
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- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $28.90 | Total: $144.50 |
| 1 | 10 | $24.48 | Total: $244.80 |
| 1 | 25 | $20.74 | Total: $518.50 |
| 1 | 50 | $17.68 | Total: $884.00 |
| 1 | 100 | $15.30 | Total: $1,530.00 |
Overview
EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.
Chemical Properties
| Molecular Formula | C19H28Cl2N4O2 |
| Molecular Weight | 415.36 |
| CAS Numbers | 1236199-60-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1C=2C(=CC(N(CCCl)CCCl)=CC2)N=C1CCCCCCC(NO)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Mehrling T, et al. The Alkylating-HDAC Inhibition Fusion Principle Taking Chemotherapy to the Next Level with the First in Class Molecule EDO-S101. Anticancer Agents Med Chem. 2016;16[1] 20-8.