Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $95.20 | Total: $476.00 |
| 1 | 10 | $80.64 | Total: $806.40 |
| 1 | 25 | $68.32 | Total: $1,708.00 |
| 1 | 50 | $58.24 | Total: $2,912.00 |
| 1 | 100 | $50.40 | Total: $5,040.00 |
Overview
BETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines.
Chemical Properties
| Molecular Formula | C43H46N10O6 |
| Molecular Weight | 798.89 |
| CAS Numbers | 2093388-62-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C1=C2C=3C(NC2=NC(C(NCCCCCC4=C5C(C(=O)N(C5)C6C(=O)NC(=O)CC6)=CC=C4)=O)=N1)=CC(=C(OC)C3)C=7C(C)=NOC7C)C=8N(CC)N=C(C8)C9CC9 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal [BET] Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61[2] 462-481.