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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $63.75 | Total: $318.75 |
| 1 | 10 | $54.00 | Total: $540.00 |
| 1 | 25 | $45.75 | Total: $1,143.75 |
| 1 | 50 | $39.00 | Total: $1,950.00 |
| 1 | 100 | $33.75 | Total: $3,375.00 |
Overview
CF53 is a highly potent, selective, and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM, and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, being very selective over non-BET bromodomain-containing proteins. CF53 exhibits potent anti-tumor activity both in vitro and in vivo.
Chemical Properties
| Molecular Formula | C24H25N7O2 |
| Molecular Weight | 443.5 |
| CAS Numbers | 1808160-52-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(nn3C)C3CC3)c21 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhao Y, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal [BET] Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61[14] 6110-6120.