Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
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- Epigenetics
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- PET/SPECT Imaging Precursors
- Customized Screening Library
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- Proteins and Antibodies
- Primary Cells
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $141.10 | Total: $705.50 |
| 1 | 10 | $119.52 | Total: $1,195.20 |
| 1 | 25 | $101.26 | Total: $2,531.50 |
| 1 | 50 | $86.32 | Total: $4,316.00 |
| 1 | 100 | $74.70 | Total: $7,470.00 |
Overview
PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation constant (KD) of 5.43 nM for BRD4(1).
Chemical Properties
| Molecular Formula | C20H18N2O2 |
| Molecular Weight | 318.37 |
| CAS Numbers | 1629277-36-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1[C@H](C=2C(C1=O)=CC=C(C2)C=3C(C)=NOC3C)C4=CC=CC=C4 |
Storage and Handling
0C Short Term, -20C Long Term
References
Montenegro RC, et al. BET inhibition as a new strategy for the treatment of gastric cancer. Oncotarget. 2016 Jul 12;7[28] 43997-44012.