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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $50.15 | Total: $250.75 |
| 1 | 10 | $42.48 | Total: $424.80 |
| 1 | 25 | $35.99 | Total: $899.75 |
| 1 | 50 | $30.68 | Total: $1,534.00 |
| 1 | 100 | $26.55 | Total: $2,655.00 |
Overview
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENLAF9, with an IC50 of 25 nM and EC50 of 205 nM for the ENL YEATS domain, and an IC50 of 311 nM and EC50 of 76 nM (CETSA) for the AF9 YEATS domain. It shows over 100-fold lower affinity for MAP3K19 (Kd = 3.5 ?M) compared to ENL YEATS (Kd = 30 nM). SR-0813 can be utilized in acute leukemia research.
Chemical Properties
| Molecular Formula | C25H32N6O3S |
| Molecular Weight | 496.62 |
| CAS Numbers | 2597186-19-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(NC1CCC1)(=O)C2=CN3C(=NC(=C3)C4=CC(NS(NCCN5CCCCC5)(=O)=O)=CC=C4)C=C2 |
Storage and Handling
0C Short Term, -20C Long Term
References
Garnar-Wortzel L, et al. Chemical Inhibition of ENLAF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7[5] 815-830.