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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $60.35 | Total: $301.75 |
| 1 | 10 | $51.12 | Total: $511.20 |
| 1 | 25 | $43.31 | Total: $1,082.75 |
| 1 | 50 | $36.92 | Total: $1,846.00 |
| 1 | 100 | $31.95 | Total: $3,195.00 |
Overview
653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 ?M.
Chemical Properties
| Molecular Formula | C20H20Cl2N2O3 |
| Molecular Weight | 407.29 |
| CAS Numbers | 1224567-46-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.NCCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O |
Storage and Handling
0C Short Term, -20C Long Term
References
Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein [CREB]-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62[24] 11423-11429.