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PF-06282999
AOB37587
CAS: 1435467-37-0
Chemical Name: 2-[6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $21.25 | Total: $106.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 100 | $11.25 | Total: $1,125.00 |
Overview
Nocvel irreversible inactivator of myeloperoxidase
Chemical Properties
| Molecular Formula | C13H12ClN3O3S |
| Molecular Weight | 325.77 |
| CAS Numbers | 1435467-37-0 |
| Solubility | DMSO |
| Purity | 99% (HPLC) |
| IUPAC/Chemical Name | 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide |
| InChl Key | ICYNYWFGIDGBRD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H12ClN3O3S/c1-20-10-3-2-7(14)4-8(10)9-5-12(19)16-13(21)17(9)6-11(15)18/h2-5H,6H2,1H3,(H2,15,18)(H,16,19,21) |
| SMILES Code | O=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PF-06282999; PF06282999; PF06282999.
References
1) Ruggeri RB, Buckbinder L, Bagley SW, Carpino PA, Conn EL, Dowling MS, Fernando DP, Jiao W, Kung DW, Orr ST, Qi Y, Rocke BN, Smith A, Warmus JS, Zhang Y, Bowles D, Widlicka DW, Eng H, Ryder T, Sharma R, Wolford A, Okerberg C, Walters K, Maurer TS, Zhang Y, Bonin PD, Spath SN, Xing G, Hepworth D, Ahn K, Kalgutkar AS. Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem. 2015 Oct 28. [Epubahead of print] PubMed PMID: 26509551.