Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
VU0092273
AOB1586
CAS 393110-43-5
Chemical Name: (4-Hydroxypiperidin-1-yl)(4-phenylethynyl)phenyl)methanone; VU0092273; VU0092273-7
23 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $75.65 | Total: $378.25 |
| 1 | 10 | $64.08 | Total: $640.80 |
| 1 | 25 | $54.29 | Total: $1,357.25 |
| 1 | 50 | $46.28 | Total: $2,314.00 |
| 1 | 100 | $40.05 | Total: $4,005.00 |
Overview
Novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5 PAM)
Chemical Properties
| Molecular Formula | C20H19NO2 |
| Molecular Weight | 305.38 |
| CAS Numbers | 393110-43-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (4-hydroxypiperidin-1-yl)-[4-(2-phenylethynyl)phenyl]methanone |
| InChl Key | FPDBSDNGFNDSSK-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H19NO2/c22-19-12-14-21(15-13-19)20(23)18-10-8-17(9-11-18)7-6-16-4-2-1-3-5-16/h1-5,8-11,19,22H,12-15H2 |
| SMILES Code | O=C(N1CCC(O)CC1)C2=CC=C(C#CC3=CC=CC=C3)C=C2 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
VU0092273, VU 0092273, VU-0092273
References
1) Sheffler DJ, Wenthur CJ, Bruner JA, Carrington SJ, Vinson PN, Gogi KK, Blobaum AL, Morrison RD, Vamos M, Cosford ND, Stauffer SR, Daniels JS, Niswender CM, Conn PJ, Lindsley CW. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5. doi: 10.1016/j.bmcl.2012.04.112. Epub 2012 Apr 30. PubMed PMID: 22607673; PubMed Central PMCID: PMC3365510.