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zr17-2
AOB33334
CAS No: 1263893-98-6
Chemical Name: 2-((2-Amino-9-(2-(diethylamino)ethyl)-9H-purin-6-yl)thio)acetic acid
807 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $41.65 | Total: $208.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 100 | $22.05 | Total: $2,205.00 |
Overview
ZR17-2 is a novel first-in-class CIRP activator — it enhances a natural stress-protective pathway, providing neuroprotective and anti-degenerative effects in research models. It’s being studied as a hypothermia-mimicking drug candidate, mostly in retinal and brain injury research.
Reported Effects:
Neuroprotection: Preserves retinal ganglion cells and visual function after perinatal asphyxia (rat models).
Anti-inflammatory / anti-apoptotic: Reduces cell death and oxidative stress markers in experimental models.
Vascular/retinal protection: Prevents retinal degeneration by improving cellular resilience to stress (PMC10967100).
Potential Applications
Research in neuroprotection (stroke, perinatal hypoxia, traumatic brain injury).
Retinal disease studies (e.g., glaucoma, ischemic retinopathy).
Could inspire future therapeutics that mimic cooling therapy in neonatal asphyxia and other ischemic conditions.
Chemical Properties
| Molecular Formula | C13H20N6O2S |
| Molecular Weight | 324.40 |
| CAS Numbers | 1263893-98-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-((2-Amino-9-(2-(diethylamino)ethyl)-9H-purin-6-yl)thio)acetic acid |
| InChl Key | QYTOGPUSMCMAMH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H20N6O2S/c1-3-18(4-2)5-6-19-8-15-10-11(19)16-13(14)17-12(10)22-7-9(20)21/h8H,3-7H2,1-2H3,(H,20,21)(H2,14,16,17) |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
zr17-2; zr172; zr17 2
References
Coderch C, Díaz de Cerio M, Zapico JM, Peláez R, Larrayoz IM, Ramos A, Martínez A, de Pascual-Teresa B. In silico identification and in vivo characterization of small molecule therapeutic hypothermia mimetics. Bioorg Med Chem. 2017 Dec 15;25(24):6597-6604. doi: 10.1016/j.bmc.2017.10.039. Epub 2017 Oct 31. PubMed PMID: 29137939
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