Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
ML221 Bulk
AOB1262B
CAS No: 877636-42-5
Chemical Name: [4-Oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl]-4-nitrobenzoate; CID-7217941
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity (mg or Unit) | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|
| 5 | $29.75 | Total: $148.75 |
| 10 | $25.20 | Total: $252.00 |
| 25 | $21.35 | Total: $533.75 |
| 50 | $18.20 | Total: $910.00 |
| 100 | $15.75 | Total: $1,575.00 |
Overview
Functional antagonist of the apelin (APJ) receptor
Chemical Properties
| Molecular Formula | C17H11N3O6S |
| Molecular Weight | 385.35 |
| CAS Numbers | 877636-42-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate |
| InChl Key | UASIRTUMPRQVFY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H11N3O6S/c21-14-8-13(10-27-17-18-6-1-7-19-17)25-9-15(14)26-16(22)11-2-4-12(5-3-11)20(23)24/h1-9H,10H2 |
| SMILES Code | O=C(OC1=COC(CSC2=NC=CC=N2)=CC1=O)C3=CC=C([N+]([O-])=O)C=C3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
ML221; ML 221; ML-221.
References
1) Roche J, Ramé C, Reverchon M, Mellouk N, Rak A, Froment P, Dupont J. Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells. Reproduction. 2017 Mar 1. pii: REP-16-0677. doi: 10.1530/REP-16-0677. [Epub ahead of print] PubMed PMID: 28250234.
2) Hall C, Ehrlich L, Venter J, O'Brien A, White T, Zhou T, Dang T, Meng F, Invernizzi P, Bernuzzi F, Alpini G, Lairmore TC, Glaser S. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017 Feb 1;386:179-188. doi: 10.1016/j.canlet.2016.11.025. PubMed PMID: 27894959.