Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $84.15 | Total: $420.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 100 | $44.55 | Total: $4,455.00 |
Overview
PD-1-IN-22 is a potent inhibitor of the programmed cell death-1 (PD-1)programmed cell death-ligand 1 (PD-L1) interaction, with an IC50 of 92.3 nM.
Chemical Properties
| Molecular Formula | C25H25N5O4 |
| Molecular Weight | 459.5 |
| CAS Numbers | 2349372-98-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(NC1=C(C)C(=CC=C1)C=2C=C3C(=CC2)OCCO3)(=O)C=4C=5N(C=C(CNCCO)C4)C=NN5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Qin M, et al. Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2019 May 9;62[9] 4703-4715.