Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $156.40 | Total: $782.00 |
| 1 | 10 | $132.48 | Total: $1,324.80 |
| 1 | 25 | $112.24 | Total: $2,806.00 |
| 1 | 50 | $95.68 | Total: $4,784.00 |
| 1 | 100 | $82.80 | Total: $8,280.00 |
Overview
SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.
Chemical Properties
| Molecular Formula | C22H30N4O3 |
| Molecular Weight | 398.5 |
| CAS Numbers | 1218816-71-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(CC1CCCC1)C2=NC(=NO2)C3=CC=C([C@@H](NC(=O)[C@@H]4[C@@H](O)CCN4)C)C=C3 |
Storage and Handling
0C Short Term, -20C Long Term
References
Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20[15] 4550-4.