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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $165.75 | Total: $828.75 |
| 1 | 10 | $140.40 | Total: $1,404.00 |
| 1 | 25 | $118.95 | Total: $2,973.75 |
| 1 | 50 | $101.40 | Total: $5,070.00 |
| 1 | 100 | $87.75 | Total: $8,775.00 |
Overview
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Chemical Properties
| Molecular Formula | C28H27NO6 |
| Molecular Weight | 473.52 |
| CAS Numbers | 447415-26-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O |
Storage and Handling
0C Short Term, -20C Long Term
References
Latika Singh, et al. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3 Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 4;81[5] 1870-6.