Categories
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- Protein Control Ligand
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $55.25 | Total: $276.25 |
| 1 | 10 | $46.80 | Total: $468.00 |
| 1 | 25 | $39.65 | Total: $991.25 |
| 1 | 50 | $33.80 | Total: $1,690.00 |
| 1 | 100 | $29.25 | Total: $2,925.00 |
Overview
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.
Chemical Properties
| Molecular Formula | C11H7NOS |
| Molecular Weight | 201.24 |
| CAS Numbers | 420849-22-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=c1[nH]c2sccc2c2ccccc12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Chiarugi A, et al. Novel isoquinolinone-derived inhibitors of poly[ADP-ribose] polymerase-1 pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. J Pharmacol Exp Ther. 2003 Jun;305[3] 943-9.