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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $32.30 | Total: $161.50 |
| 1 | 10 | $27.36 | Total: $273.60 |
| 1 | 25 | $23.18 | Total: $579.50 |
| 1 | 50 | $19.76 | Total: $988.00 |
| 1 | 100 | $17.10 | Total: $1,710.00 |
Overview
JH-II-127 is an oral inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting WT LRRK2, G2019S LRRK2, and A2016T LRRK2 with IC50 values of 6.6 nM, 2.2 nM, and 47.7 nM, respectively.
Chemical Properties
| Molecular Formula | C19H21ClN6O3 |
| Molecular Weight | 416.86 |
| CAS Numbers | 1700693-08-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]cc(Cl)c12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Discovery of a Pyrrolopyrimidine [JH-II-127], a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor[J]. ACS Medicinal Chemistry Letters, 2015, 6[5] 584-589.